Bayer Technology Services GmbH
51368 Leverkusen, Germany
Phone: +49 214 30 37414
Nanotoxicity: synthesis and characterisation of nano-objects for toxicological evaluation (Project 12)
Related Work Packages: WP1, WP2, WP3, WP4 (see WP Table).
Emilia received her Master degree in Environmental Chemistry in 2008 from the Jagiellonian University in Cracow (Poland). From September 2006 till June 2007 she was working in a research project, partially funded by the Socrates/Erasmus program, on advanced polymer surface coating to prevent biofouling. The work was carried out in the surface engineering and nanotechnology cluster of Materials Science and Technology of Polymers group at the University of Twente in Enschede (The Netherlands). After graduation, she became a junior expert at the National Research Institute in Warsaw (Poland), where she was working on a development of the principles of Polish environmental policy and strategies, and participation in international activities. In 2009 she joined the Marie Curie Initial Training Network BIOMINTEC working on a development of superhydrophobic surfaces by silicatein-mediated silica deposition on S-layers at Nano-S Biotechnology company in Vienna (Austria). In May 2011 she moved to Leverkusen (Germany) to start her PhD research at Bayer Technology Services as a Marie Curie Fellow of the NanoTOES project.
Nanoparticles (NPs) exhibit a variety of unique chemical and physical properties that have made them central components in an array of emerging technologies. Engineered NPs are rapidly becoming a part of our daily life in a form of cosmetics, food packaging or drug delivery systems. With the rapid growth of NPs-based products, researchers, manufacturers and consumers are deeply concerned with their safety and environmental impact. Toxicological studies with engineered NPs have recently begun to increase. Nevertheless, lots of the literature shows variable conclusions, concerning similar materials. It is becoming recognized that reports on the toxicity of nanomaterials are often based on insufficient characterization of the NPs or not accurate experimental protocols. Since it is getting known that biological activity of NPs depends on physico-chemical parameters, proper and accurate particle characterization is a basic requirement for understanding biological effects and providing reproducibility.
The main idea of the project is to develop protocols for synthesis of nano-dispersion with well-defined properties and to develop SOPs for characterization of NPs with different spectroscopic and microscopic methods (TEM, SEM, CLSM, XPS, SIMS, Zeta-Potential, etc.). The carefully synthesized and extensively characterized NPs are subsequently used for their toxicological evaluation.
Dr. Matthias Voetz (Bayer), Dr. Stefanie Eiden (Bayer), Prof. Albert Duschl (PLUS)
Final project update: Emilia Izak successfully defended her thesis on July 24th, 2014.
Her thesis title was “Nanotoxicology: synthesis and characterization of silver and silica nanoparticles for their toxicological evaluation”.