Laboratory of Cellular and Developmental Neurobiology,
Institute of Experimental Medicine,
Hungarian Academy of Sciences, (IEM-HAS)
1083 Budapest, Szigony Street 43,
Mob: +36 2054 200 25
Tel: +36 1 210 9966
Fax: +36 1 210 9423
Interaction of NP with neural stem- and tissue-type cells
Related Work Packages: WP1 and WP2 (see WP Table).
Murali obtained his Bachelor degree in Pharmaceutical sciences in 2005 from The Tamilnadu Dr. MGR Medical University, Chennai, India, after his bachelor studies he worked in the area of synthetic and natural plant molecules for anti-inflammatory, anti-cancer and anti-tuberculosis.
He obtained his Master’s degree in Nanoscience and Nanotechnology at the Nano-biotechnology and Bio analysis Group, University of Rovira I Virgili Tarragona, Spain, His thesis was entitled “Optimization of separation and isolation of circulating cell-free fetal DNA for non-invasive prenatal diagnosis”. In September 2011 he started his Marie Curie Fellowship as an early stage researcher (PhD student) at the Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest.
- K. Murali, et al., Synthesis, antibacterial, and antitubercular studies of some novel isatin derivatives, Med. Chem. Res., 2012, 21(12), 4335-4340.
- K. Murali, et al., In vitro cytotoxicity and induction of apoptosis by ruthenium(II) complexes in HL-60 and K-562, Med. Chem. Res., 2012, 21(7), 1120-1126.
- K. Murali et al., Synthesis and anticancer activity of some new series of 1,4 dihydropyridine derivatives, Indian Journal of Chemistry, 2011, 50B, 1140-1144.
- K. Murali et al., Synthesis, characterization, analgesic, anti-inflammatory and antimicrobial evaluation of novel Isatin Derivatives, Der Pharma Chemica, 2010, 2(1): 28-37.
The vast majority of cells in the central nervous tissue are protected from extraneural chemical/physical insults by multiple (blood-brain, blood-liquor, liquor-tissue) barriers. The extracellular environment of the brain tissue is also controlled by potent glial uptake mechanisms. While “natural” load of NP (from dust, water, etc.) has not been shown to endanger neural functions, we should be aware of potential harm caused by artificially increased amounts of NP in the environment or by direct load of NP as diagnostic probe-materials or by the intended use of nanodevices.
Primary cultures of rat neurons and/or glial cells, neural stem cell clones and in vitro cell differentiation model systems will be investigated. Besides in vitro analyses, the potential effects of NP on the developing and mature central nervous tissue will be investigated by surgical and histological/immunocytochemical methods in early stages of the embryonic tissue genesis in rodents, when the neural tissue is not yet protected by specialised barriers, and in mature animals, when NP are expected to accumulate at blood-brain, blood-liquor and internal cellular barrier interfaces. Especially his research focused on selected aspects of “neural nanosafety”.
Prof. Dr. Emilia Madarasz (IEM-HAS)