Inorganic Nanoparticles Group
Institution of Nanotechnology (ICN)
Campus UAB, Edifici Q (ETSE)
3rd. floor – Office QC/3115
08193 Bellaterra (Barcelona), Spain
Telephone: (+34) 93 586 8018
The life of NP in contact with biological media and entities (Project 9)
Related Work Packages: WP1, WP3, WP4 (see WP Table).
Ngoc obtained her Bachelor degree in Chemical Engineering in 2008 from Ho Chi Minh City University of Technology (Vietnam), where she worked on the synthesis of oil-absorbent materials using agricultural by-products. After graduation, she pursued her Masters in Chemical Engineering at the National Taiwan University of Science and Technology (NTUST), in Taiwan. She completed it in July 2010, defending her thesis entitled “Novel synthesis of gold nanoparticles for bio-applications”. She became then a Research Assistant at the National Taiwan University (NTU), where she continued working on the synthesis of nanoparticles, till in 2011 she moved to Barcelona (Spain) to start her Marie Curie Fellowship within the NanoTOES project.
- Y. Tai, N. T. T. Tran, Y. C. Tsai, J. Y. Fang, L. W. Chang, One-step synthesis of highly biocompatible multi-shaped gold nanostructures with fruit extract. IET Nanobiotechnoly 5(2), 52-59 (2011).
- N. T. T. Tran et al., Direct Synthesis of Rev Peptide-Conjugated Gold Nanoparticles and Their Application in Cancer Therapeutics. Bioconjugate Chemistry 22(7), 1394-1401 (2011).
NPs are gaining more and more interest based on their enormous potential applications. A huge amount of research has been carried out successfully in the generation of nanoparticles with various size and shape. However, the main concern that arises when the NPs are in use, especially in biomedicine, is their probable toxicity or their impact on human health and on the environment.
Therefore, it is essential to determine the factors that impact the toxic behavior of the particles, as well as to develop reliable standard methods for investigating the interaction between NPs and biological systems. In that context, Ngoc’s project aims to explore the interaction of inorganic and biological matter at the nanoscale, focusing on what happens to NPs when they are in contact with biological entities.
Several aspects are being studied including protein corona formation, aggregation, dissolution, corrosion of NPs and evolution of the interaction. Another goal of this research is to identify the suitable biomarkers of cytotoxicity, since the strongly plasmonic absorption of NPs interfere with the optical properties of dyes used in biological assays.
Prof. Dr. Víctor Puntes (NanoTOES PI, ICN), Dr. Eudald Casals (ICN).
Final project update: Ngoc Tran successfully defended her thesis on October 17th, 2014.
Her thesis title was “The life of nanoparticles in contact with biological media and entities”.