Institute for Biomedical Technologies (ITB)
National Research Council (CNR)
Via G. Moruzzi No. 1
56124, Pisa, Italy
In vitro models of acute vs. chronic/repeated exposure for assessing nanoparticle-induced inflammation (Project 2)
Related Work Packages: WP1, WP2, WP3, WP4 (see WP Table).
Yang Li obtained his Bachelor degree in Ecology from Hebei Agricultural University of China in 2008, which gave him a strong background in environment, large-scale ecological problems and integrated problems. He then decided to pursue his Master degree in molecular biology field and studied the human iron metabolism from 2008 to 2009 at Hebei Normal University, China. From 2009 to 2011, he studied at the key laboratory for biological effects of Nanomaterials and Nanosafety at the Chinese National Center for Nanoscience and Technology (CAS) in Beijing, where he had worked on relevant project that focus on the biosafety issue of carbon nanomaterials (CNTs and Graphene). He tried to use molecule method to investigate the deeply mechanism of the nanoparticles which have side effects on human. After he obtained his master degree in Physiology in 2011, he moved to CNR in Pisa (Italy) to start his Marie Curie Fellowship within the NanoTOES project as a PhD student.
- 1. Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway. Small, 2013, 9(22):3799-811.
- Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. Nanotoxicology, 2012, 6(5): 526-542.
- Yang Li, Ying Liu, Yujian Fu, Taotao Wei, Laurent Le Guyader, Ge Gao, Ru-Shi Liu, Yanzhong Chang, Chunying Chen. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials, 2012, 33(2):402-11.
- Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials. NPG Asia Materials, 2012, 4, e32.
Currently, more and more nanoparticles (NPs) are used in daily life. That situation challenges human beings when we are exposed to NPs. The innate immune systems of human being provide immediate defence against infection, include NPs’ invasion. Therefore, what is the fate of NPs when they face the innate immune system after entry into the body? How does our immune system defend us when facing the challenge of NPs? Moreover, do NPs interfere with the inflammatory response, which is considered as an extremely important immune system reaction in our defence when faced with dangerous infections by bacteria, viruses or fungi. In this context, Yang’s project aim to find out the NPs’ interference with immune system by using in vitro models. In addition, lipopolysaccharide (LPS), as a biological contaminant of NPs that can have a major influence in triggering inflammation, will also well document in this research.