Project 12 (Bayer)
Project 12: Synthesis and characterisation of nano-objects for health safety and environmental investigation
Fellow: Emilia Izak (ESR11), 36 months
Tutor: Dr. Stefanie Eiden, Dr. Matthias Voetz (Bayer)
The work will be performed by an ESR in the division Process Technology from Bayer Technology Services (BTS). Bayer Technology is the ideal partner for delivering technical solutions and services along the whole life-cycle of processes, plants and products. BTS can point to a track record of over 2 billion Euro total investment volume annually. It provides technology platforms for synthesis, catalysis, biotechnology, nanotechnology and nanoanalytic, in-silico technologies, process synthesis, process management systems, product design, and unit operations. BTS operates several labs for catalyst and process development for the production of nanoobjects, as well as for the modification and functionalization of nanoobjects and also for the analysis of nanomaterials. In a proposal for a BMBF project, BTS has a WP for synthesis of Silver and Silica NP and to develop a SOP for the characterization of different NP out of the BMBF project. There are two different tasks for an ESR within NanoTOES:
- To develop protocols for the synthesis of silver and silica nano-dispersion with well-defined properties for different particle diameter: The project includes the production of silver and fluorescent silica particles and the detailed characterization of these particles. The effect of synthesis conditions on the particles properties should be determined. At BTS the silver particles are synthesized in a pilot plant process, so that particles out of different process steps are available for characterization. Furthermore the size and surface chemistry of the particles will be varied and the influence of these parameters on the particle properties will be determined. In addition novel fluorescent silica particles will be developed.
- To develop SOPs for characterization of NP in powder form and dispersions with different spectroscopic and microscopic Methods (TEM, SEM, CLSM, ESCA,SIMS, Zeta-Potential, etc.): The expertise and techniques which are available at BTS will be used to develop a SOP for a complete characterization of nanomaterials for the use in HSE investigations. This work will be done in strong correlation to the work in the ISO TC229 and on OECD level. These methods will be used to characterize NP ageing under different conditions as well as change of NP characteristics induced by exposure to biological agents.
Main skills acquired are a multitude of physical characterization procedures for NP, working under industrial GLP conditions, establishment of SOPs, basic biological assays. Secondments to partners 3 (lab-on-chip methods), 4 (standardized biological assays), 11 (characterization of airborne particles).
In WP3 (tasks 3.2 and 3.3) and WP4 (task 4.5).